Freie Universität Berlin
Fachbereich Biologie, Chemie, Pharmazie - Institut für Chemie und Biochemie
The EU project GlycoSpec aims to investigate the reaction mechanism in glycosylation, which is crucial for building oligosaccharides. For this purpose, a detailed structural analysis of the sugar intermediate, the glycosyl cation, is required. The approach involves using a cryogenic helium droplet instrument to capture the intermediate in the gas phase. Subsequently, a laser irradiates the target ion, revealing its vibrational pattern. This mass spectrometry-based technology provides a snapshot of the SN1 mechanism. A series of chemical reactions are then conducted to correlate the gas-phase structure with the synthesis in solution.
Research assistant (postdoc) (m/f/d)
full-time job
limited to 31.01.2026 (end of project)
salary grade (Entgeltgruppe) 13 TV-L FU
reference code: WiMi-AGPagel_230
Tasks
- Design and synthesis of sugar building blocks with diverse functional group modifications
- develop and execute chemical reactions to probe the glycosylation mechanism
- perform in-depth spectrometric analysis of oligosaccharides using Nuclear Magnetic Resonance (NMR), mass spectrometry, and infrared spectroscopy (IR)
Requirements
- Completed scientific degree (M.Sc. or Diploma) and completed doctorate in organic or carbohydrate chemistry
(Professional) Experience:
- Experience in carbohydrate chemistry
- experience in glycan synthesis
Desirable:
- Experience in the synthesis of oligosaccharides and mechanism studies in glycosylation reactions.
- proficient in written and spoken English.
How to apply
We look forward to receiving your application, which should include the following documents:
- a one-page letter of motivation why you want to work in EU project GlycoSpec, together with details of previous research experience and future goals
- your CV (including a list of publications if applicable)
- evidence of your academic achievements including copies of your Bachelor's, Master's and PhD degrees
- at least two letters of support
Applications should be sent by e-mail, together with all documents listed above, indicating the reference code no later than October 21st 2024 in PDF format (preferably as one document) to Dr. Kevin Pagel: miriam.mahn@fu-berlin.de or postal to
Freie Universität Berlin
Fachbereich Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie
Frau Prof. Dr. Kevin Pagel
Altensteinstr. 23A
14195 Berlin (Dahlem)
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Freie Universität Berlin is an equal opportunity employer.
Facts
| Published | 02.10.2024 |
|---|---|
| Category | Research assistant |
| Location | Germany, Berlin, Berlin |
| Area of responsibility | Chemistry, Research, Natural Sciences |
| Start date (earliest) | Earliest possible |
| Duration | limited to 31.01.2026 (end of project) |
| Full/Part-time | full-time job |
| Remuneration | salary grade (Entgeltgruppe) 13 TV-L FU |
| Working language and expected level |
|
| Homepage | https://www.bcp.fu-berlin.de/en/index.html |
Requirements
| Field of study | Natural sciences and mathematics, Biochemistry, Chemistry |
|---|
Contact
| Reference number | WiMi-AGPagel_230 |
|---|---|
| Contact person | Herr Prof. Dr. Kevin Pagel |
Apply
| Application deadline | 21.10.2024 |
|---|---|
| Reference number | WiMi-AGPagel_230 |
| By post | Freie Universität Berlin
|
| By email | miriam.mahn@fu-berlin.de |