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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Insti­tute of Labor­at­ory Medi­cine, Clin­ical Chem­istry and Patho­bi­o­chem­istry

The Char­ité - Uni­ver­si­täts­med­izin Ber­lin is a joint med­ical fac­ulty, which ser­ves both Freie Uni­ver­si­tät Ber­lin and Hum­boldt Uni­ver­si­tät zu Ber­lin. As one of the lar­gest uni­ver­sity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in rese­arch, teach­ing and clin­ical care. The Char­ité uni­ver­sity hos­pital has also made a name for its­elf as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

Sci­entific Assist­ant (65%, labor­at­ory medi­cine)

Cha­rité Cam­pus Mitte

Work­ing field:

In a pro­ject fun­ded by the Ger­man Research Found­a­tion (DFG) we intend to invest­ig­ate pro­tein tyr­osine phos­phatases (PTPs) as novel molecu­lar tar­gets of inflam­ma­tion-medi­ated insulin res­ist­ance and skeletal muscle atrophy. The pro­ject is loc­ated at the inter­face between medi­cine, molecu­lar bio­logy, bio­chem­istry and cell bio­logy and rep­res­ents a closely linked col­lab­or­a­tion with the group of Prof. Fielitz, Uni­versitätsmed­izin Gre­if­swald, Dept. of car­di­ology. The aim is to gain a bet­ter under­stand­ing of the role of PTPs in peri­pheral insulin res­ist­ance in skeletal muscle dur­ing sepsis or inflam­ma­tion. The object of invest­ig­a­tion is in par­tic­u­lar the insulin sig­nal­ing in the skeletal muscle. The pro­ject, loc­ated mainly at the Cen­ter for Car­di­ovas­cu­lar Research of the Char­ité, offers the oppor­tun­ity to work together in one of the best med­ical uni­versit­ies in Ger­many with numer­ous sci­entific cooper­a­tion pos­sib­il­it­ies. The pre­par­a­tion of a dis­ser­ta­tion is desired and is sup­por­ted (Dr. rer. nat., Dr. rer. medic.).

Your area of respons­ib­il­ity
  • molecu­lar bio­logy
  • hand­ling of DNA, RNA and pro­teins
  • exper­i­mental ana­lysis in cell cul­ture
  • ana­lyses in mur­ine tis­sue and poten­tially animal exper­i­ments
  • ana­lyt­ical tech­niques (gel elec­tro­phoresis, west­ern blot­ting, poly­merase chain reac­tion, his­to­logy, immun­o­his­to­chem­istry)
  • Prox­im­ity Lig­a­tion Assay in situ
  • Pro­tein Tyr­osin Phos­phatase activ­ity assays
  • planned pub­lic­a­tion of res­ults in high-qual­ity peer reviewed journ­als
  • attend­ing insti­tute-based sci­entific meet­ings
  • attend­ing (inter­na­tional) sci­entific meet­ings and present­ing res­ults

Sci­entific staff is given suf­fi­cient time to carry out their own sci­entific work in accord­ance with their employ­ment rela­tion­ship.

Require­ments:

The can­did­ate must have fully com­pleted their mas­ter´s degree (or com­par­able) by the join­ing date of this pro­ject. Ideally, the stud­ies were done in the field of bio­chem­istry, bio­logy, bio­tech­no­logy, or phar­macy. Closely related fields are pos­sible provided that all require­ments, out­lined in the areas of respons­ib­il­ity, are ful­filled. Ideally, the can­did­ate has exper­i­ence in exper­i­mental research and provides know­ledge of the depic­ted meth­ods. Some back­ground know­ledge in anti­body/enzyme and fur­ther pro­tein and DNA/RNA hand­ling would be favor­able. Ana­lyt­ical exper­i­ences in gel elec­tro­phoresis, west­ern blot­ting, and PCR is of advant­age.
The can­did­ate must be able to work both inde­pend­ently and in a team and is inter­ested in par­ti­cip­at­ing in the char­ac­ter­isa­tion of cel­lu­lar sig­nalling path­ways, and must be motiv­ated to present the res­ults of the pro­ject in pub­lic­a­tions. Since the pro­ject involves exper­i­ments with labor­at­ory anim­als, it is neces­sary that you acknow­ledge the need for animal exper­i­ments for med­ical pur­poses. Apart from this, the ideal can­did­ate is self-motiv­ated and has an interest in work­ing in an envir­on­ment (Cen­ter for Car­di­ovas­cu­lar Research at the Char­ité) with people from dif­fer­ent nation­al­it­ies.

How to ap­ply:

Please send your applic­a­tion as a single PDF file of max. 5 MB quot­ing the ref­er­ence numer to:

Char­ité - Uni­versitätsmed­izin Ber­lin
kai.kappert@charite.de

Name of con­tact per­son:

kai.kappert@charite.de
Phone no.: 030-405026207; 030-450525308

DIE CHAR­ITÉ – UNI­VERSITÄTSMED­IZIN BER­LIN makes its human resources decisions based on
suit­ab­il­ity, com­pet­ence and pro­fes­sional per­form­ance. At the same time, it strives to increase the per­cent­age of women in man­age­ment pos­i­tions and takes this into con­sid­er­a­tion where can­did­ates are equally qual­i­fied within the lim­its of what is leg­ally pos­sible. Applic­a­tions from people with a migrant back­ground are also expli­citly wel­come. Severely dis­abled applic­ants are given pref­er­en­tial con­sid­er­a­tion in the case of can­did­ates with equal qual­i­fic­a­tions. An exten­ded cer­ti­fic­ate of con­duct must be sub­mit­ted. Any travel expenses incurred can­not be reim­bursed.

Data pro­tec­tion notice: Char­ité points out that per­sonal data is stored and pro­cessed as part of the applic­a­tion pro­cess in dif­fer­ent areas of Char­ité (e.g. fac­ulty, staff com­mit­tee, human resources depart­ment). Fur­ther­more, the data may be trans­ferred or pro­cessed within the group as well as in loc­a­tions out­side the group (e.g. author­it­ies) to pro­tect legit­im­ate interests. By apply­ing, you agree toour data pro­tec­tion reg­u­la­tions and terms of use, which you can find here https://www.charite.de/service/datenschutz/bewerbungsverfahren/.