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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin

The Char­ité - Uni­ver­si­täts­med­izin Ber­lin is a joint med­ical fac­ulty, which ser­ves both Freie Uni­ver­si­tät Ber­lin and Hum­boldt Uni­ver­si­tät zu Ber­lin. As one of the lar­gest uni­ver­sity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in rese­arch, teach­ing and clin­ical care. The Char­ité uni­ver­sity hos­pital has also made a name for its­elf as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

PhD can­did­ate

Depart­ment of Gast­roen­ter­o­logy, Infec­ti­ology and Rheum­at­o­logy

Work­ing field:

We are look­ing for a Ph.D. stu­dent to join the Inflam­mat­ory Mech­an­isms Group (Hegazy lab) at the Depart­ment of Gast­roen­ter­o­logy, Infec­ti­ology and Rheum­at­o­logy at Char­ité Uni­versitätsmed­izin in Ber­lin. The Hegazy lab was estab­lished in early 2018 and is loc­ated at the Depart­ment of Gast­roen­ter­o­logy, Cam­pus Ben­jamin Frank­lin as well as the Ger­man Rheum­at­ism Research Centre Ber­lin (DRFZ). The pos­i­tion is fun­ded by the Volk­swa­gen­Stif­tung through the Lichten­berg Pro­fess­or­ship pro­gram.

IYour area of respons­ib­il­ity:

The mam­malian gastrointest­inal tract is the largest organ of the human body beside the skin. It is the organ con­tain­ing the largest num­ber of immune cells and har­bours a large and diverse pop­u­la­tion of com­mensal bac­teria that exist in a sym­bi­otic rela­tion­ship with the host. In recent years, it has become increas­ingly clear that the com­pos­i­tion of this gastrointest­inal micro­bi­ome and its inter­ac­tion with the host immune sys­tem strongly influ­ences the health of the host. Deci­pher­ing the com­plex inter­play between both the genetic and envir­on­mental factors and the micro­bi­ota, is there­fore of great bio­med­ical import­ance.
One dis­ease com­plex, in which mal­ad­apt­a­tion in this host micro­bial dia­logue is involved, is inflam­mat­ory bowel dis­ease (IBD). Here, this mal­ad­apt­a­tion leads to an aber­rant immune response in the gut, res­ult­ing in recruit­ment of vari­ous lymph­oid and myel­oid effector cell pop­u­la­tions and inflam­ma­tion of gut tis­sue. The exact aeti­ology of IBD remains uncer­tain, but it is a mul­ti­factorial dis­ease that involves a com­plex inter­play between genetic, envir­on­mental, micro­bial, and immune factors.
This pro­ject will com­bine T cell immun­o­logy, mucosal immun­o­logy and patient samples to identify the envir­on­mental, micro­bial, and inflam­mat­ory drivers that pro­mote mal­ad­apt­a­tion in tis­sue-res­id­ent T cells. This pro­ject will use a com­bin­a­tion of cut­ting edge tech­no­lo­gies, high through­put cul­ture meth­ods, and ana­lysis of well defined patient cohorts. These stud­ies will uncover new path­ways involved in induc­tion and reg­u­la­tion of tis­sue res­id­ent T cells, bac­terial inter­ac­tion and intest­inal inflam­ma­tion that may offer new thera­peutic tar­gets in inflam­mat­ory dis­eases such as IBD.

Require­ments:

The pro­ject offers the oppor­tun­ity to per­form cut­ting-edge research in an ener­getic research envir­on­ment with excel­lent tech­nical facil­it­ies.
We are look­ing for highly motiv­ated can­did­ates with a dip­loma/mas­ter degree (or equi­val­ent). Can­did­ates should be highly inter­ested in study­ing Immun­o­logy, host-micro­bi­ota inter­ac­tion and a good indi­vidual and team-work­ing abil­ity is required. Exper­i­ence in immun­o­logy, micro­bi­o­logy, mul­ti­para­meter flow cyto­metry, and/or animal hand­ling would be wel­come.

How to ap­ply:

Applic­a­tions should include a CV, a short descrip­tion of pre­vi­ous exper­i­ences and tech­nical skills, and two or three ref­er­ences. Please sub­mit your applic­a­tion by May 31, 2020. Late applic­a­tions will be con­sidered until the pos­i­tion is filled.

If you have fur­ther ques­tions, please con­tact Prof. Dr. Dr. Ahmed Hegazy (Email: ahmed.hegaty@charite.de)

Employ­ees are grouped into pay scales accord­ing to their qual­i­fic­a­tions and per­sonal require­ments. You can find our col­lect­ive bar­gain­ing agree­ments (Tari­fver­träge) here:
https://www.charite.de/en/careers/

DIE CHAR­ITÉ – UNI­VERSITÄTSMED­IZIN BER­LIN makes its human resources decisions based on suit­ab­il­ity, com­pet­ence and pro­fes­sional per­form­ance. At the same time, it strives to increase the per­cent­age of women in man­age­ment pos­i­tions and takes this into con­sid­er­a­tion where can­did­ates are equally qual­i­fied within the lim­its of what is leg­ally pos­sible. Applic­a­tions from people with a migrant back­ground are also expli­citly wel­come. Severely dis­abled applic­ants are given pref­er­en­tial con­sid­er­a­tion in the case of can­did­ates with equal qual­i­fic­a­tions. An exten­ded cer­ti­fic­ate of con­duct must be sub­mit­ted. Any travel expenses incurred can­not be reim­bursed.

Data pro­tec­tion notice:

Char­ité points out that per­sonal data is stored and pro­cessed as part of the applic­a­tion pro­cess in dif­fer­ent areas of Char­ité (e.g. fac­ulty, staff com­mit­tee, human resources depart­ment). Fur­ther­more, the data may be trans­ferred or pro­cessed within the group as well as in loc­a­tions out­side the group (e.g. author­it­ies) to pro­tect legit­im­ate interests. By apply­ing, you agree to our data pro­tec­tion reg­u­la­tions and terms of use, which you can find here:

https://www.charite.de/service/datenschutz/bewerbungsverfahren/