Charité - Universitätsmedizin Berlin - Charité Campus Mitte
Located in the heart of Berlin, the Charité - Universitätsmedizin Berlin is one of the largest and most research-intensive medical faculties in Europe. The Beling laboratory at the Charité's Institute of Biochemistry is known for its research on the cellular stress response to viral infection. We tackle the question how the IFN-triggered ISG15-mediated antiviral defense program, leading to posttranslational protein ISGylation, controls viral replication and how such pathways render injured cells resistant to the detrimental consequences of IFN signaling. We have a specific focus on cellular stress response mechanism upon activation of IFN signaling in the heart muscle.
PhD Position - crosstalk ISG15-Usp18 in cardiac inflammation
CC02, Institute of Biochemistry
We are looking for an enthusiastic and determined doctoral researcher to join Prof. Antje Beling's laboratory at the Charité - Universitätsmedizin Berlin, Institute of Biochemistry. We encourage the application of a highly motivated and reliable candidate with a Master degree in life sciences (see below). We seek for a scientist willing to integrate into the various research networks at the Charité research environment, with a focus on infectious biology, immunology (ZIBI) and cardiac sciences (Young-DZHK). We expect your commitment to become a member of a structured graduate program and actively participate in workshops, retreats and lab rotations within this DFG-funded project. The ideal candidate will perform and analyze experiments in S2 labs to define the molecular crosstalk between USP18, ISG15 and IFNAR in specific heart cells upon perturbation by infection and sterile inflammation. Focusing on the crosstalk between ISG15 with USP18 in a humanized mouse model, this project will define therapeutic aspects of protein ISGylation/ISG15 and Usp18. We encourage the application of scientists with a strong interest in infectious biology and infection-triggered innate regulatory pathways at the crossroad of antiviral defense and control of cellular stress responses.
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.
Masters degree in veterinary medicine, infectious biology, biochemistry, molecular medicine, human biology or equivalent
Motivation and productivity ideally documented in published research articles
Desirable are experimental skills in molecular biology and protein biochemistry, cell culture, virology, mouse studies, immunology (multi-color flow cytometry)
Qualification for work with animal models (FELASA B certificate) recommended
DIE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed. Data protection notice: Charité points out that personal data is stored and processed as part of the application process