Charité - Universitätsmedizin Berlin - Berlin Institute of Health (BIH) - Stem Cell Core Facility
The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
Postdoc in stem cell and organoid research
Charité Campus Virchow-Klinikum
We are looking for an enthusiastic and outstanding postdoctoral candidate for a central technology provision project in the Collaborative Research Centre/Transregio 296 LocoTact funded by the DFG. The LocoTact CRC-TR aims to dissect the local control of thyroid hormone action in physiology and pathophysiology (https://www.uni-due.de/crctr296/). The interdisciplinary research consortium will take advantage of sophisticated in vitro tools such as 3D organoids derived from human pluripotent stem cells (hPSC) to facilitate the studies on the local control of thyroid hormone action in translationally relevant human model systems.
The postdoc will be given sufficient time for his own scientific work in accordance with his employment contract.
Your area of responsibility:
The candidate will be expected to establish differentiation protocols based on published methods and to further develop and standardize them in close collaboration with individual consortium partners regarding their specific project needs. Additionally, the candidate will set up state-of-the-art methods for analysis of 3D organoids (single cell RNA sequencing, 3D high content imaging).
Area of work:
Use of hPSC to generate 2D, 3D and organoid models of the liver, brain and heart.
Organoid engineering: explore and establish perfusion systems, organoid-on a chip technology
Genetic engineering of hPSC using CRISPR/Cas
Multidimensional microscopy, high content microscopy and high content analysis.
Single cell sequencing
Teaching and supervision of students and researchers applying the established methods
We are looking for a solution-oriented, organizational and positive mindset and flexible personality. The ability to work in a highly collaborative environment both independently and as part of the team is essential.
Graduate degree in Biology, Biotechnology, Biochemistry, or similar and a PhD degree in cell/molecular/developmental/stem cell biology/ or similar, with a track-record of successful scientific work.
strong background in cell and molecular biology. Alternatively, candidates with an engineering background applied to cell biology are also encourage to apply.
Excellent skills in handling primary cells or stem cells.
Experience using organoids and/or next-generation sequencing, bioinformatics or multidimensional imaging are considered an advantage
Excellent English communication skills, both oral and written, are prerequisite for the successful candidate.
How to apply:
The application must include (in pdf format):
Motivation letter (describing the applicant long-term research vision and why the applicant thinks, is the right one to fill this position).
Curriculum vitae incl. education, experience, previous employments, language skills and other relevant skills and list of publications.
List of three references (full address, incl. email and phone number).
Please send all application documents, e.g. cover letter, curriculum vitae, certificates, attestations, etc. to the following address, quoting the reference number
DIE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed.
Data protection notice: Charité points out that personal data is stored and processed as part of the application process in different areas of Charité (e.g. faculty, staff committee, human resources department). Furthermore, the data may be transferred or processed within the group as well as in locations outside the group (e.g. authorities) to protect legitimate interests. By applying, you agree to