The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
Department of Gastroenterology, Infectiology and Rheumatology
We are looking for a Ph.D. student to join the Inflammatory Mechanisms Group (Hegazy lab) at the Department of Gastroenterology, Infectiology and Rheumatology at Charité Universitätsmedizin in Berlin. The Hegazy lab was established in early 2018 and is located at the Department of Gastroenterology, Campus Benjamin Franklin as well as the German Rheumatism Research Centre Berlin (DRFZ). The position is funded by the VolkswagenStiftung through the Lichtenberg Professorship program.
IYour area of responsibility:
The mammalian gastrointestinal tract is the largest organ of the human body beside the skin. It is the organ containing the largest number of immune cells and harbours a large and diverse population of commensal bacteria that exist in a symbiotic relationship with the host. In recent years, it has become increasingly clear that the composition of this gastrointestinal microbiome and its interaction with the host immune system strongly influences the health of the host. Deciphering the complex interplay between both the genetic and environmental factors and the microbiota, is therefore of great biomedical importance.
One disease complex, in which maladaptation in this host microbial dialogue is involved, is inflammatory bowel disease (IBD). Here, this maladaptation leads to an aberrant immune response in the gut, resulting in recruitment of various lymphoid and myeloid effector cell populations and inflammation of gut tissue. The exact aetiology of IBD remains uncertain, but it is a multifactorial disease that involves a complex interplay between genetic, environmental, microbial, and immune factors.
This project will combine T cell immunology, mucosal immunology and patient samples to identify the environmental, microbial, and inflammatory drivers that promote maladaptation in tissue-resident T cells. This project will use a combination of cutting edge technologies, high throughput culture methods, and analysis of well defined patient cohorts. These studies will uncover new pathways involved in induction and regulation of tissue resident T cells, bacterial interaction and intestinal inflammation that may offer new therapeutic targets in inflammatory diseases such as IBD.
The project offers the opportunity to perform cutting-edge research in an energetic research environment with excellent technical facilities.
We are looking for highly motivated candidates with a diploma/master degree (or equivalent). Candidates should be highly interested in studying Immunology, host-microbiota interaction and a good individual and team-working ability is required. Experience in immunology, microbiology, multiparameter flow cytometry, and/or animal handling would be welcome.
How to apply:
Applications should include a CV, a short description of previous experiences and technical skills, and two or three references. Please submit your application by May 31, 2020. Late applications will be considered until the position is filled.
Employees are grouped into pay scales according to their qualifications and personal requirements. You can find our collective bargaining agreements (Tarifverträge) here: https://www.charite.de/en/careers/
DIE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed.
Data protection notice: