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Offer 66 out of 77 from 11/11/21, 14:47

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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Berlin-Oxford Centre for Advanced Studies

Die Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin ist eine gemein­same Ein­rich­tung der Freien Uni­ver­si­tät Ber­lin und der Hum­boldt-Uni­ver­si­tät zu Ber­lin. Sie hat als eines der größ­ten Uni­ver­si­täts­kli­nika Euro­pas mit bedeu­ten­der Geschichte eine füh­rende Rolle in For­schung, Lehre und Kran­ken­ver­sor­gung inne. Aber auch als moder­nes Unter­neh­men mit Zer­ti­fi­zie­run­gen im medi­zi­ni­schen, kli­ni­schen und im Manage­ment-Bereich tritt die Cha­rité her­vor

Postdoctoral Scientist - Microbiology, Systems Biology, Functional Omics

CC02, Department für Biochemie | Charité Campus Mitte

Working field:

Brief description of field of application

Located in the heart of Berlin, Charité – Universitätsmedizin Berlin is one of Europe's largest and most research-intensive medical universities. The present position is a postdoctoral project that addresses the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance. This is a joint project between the group of Markus Ralser (Director of Institute of Biochemistry) and research at the University of Oxford, headed by Craig MacLean and Rachel Wheatley. This project is funded through the Berlin University Alliance and part of the Ox|Ber Oxford/Berlin Research Partnership. We are leaders in microbiology and metabolism research, employing large-scale, ultra-fast proteomics and evolutionary genomics to investigate antimicrobial resistance and tolerance mechanisms in bacterial and fungal pathogens.

We are looking for a highly enthusiastic postdoctoral scientist to investigate the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance (AMR), with particular focus on the multi-drug resistant bacterium Pseudomonas aeruginosa (PA) and the opportunistic fungal pathogen Candida albicans (CA). This position will be formally based at the Charité in Berlin, but will conduct part of the project at the University of Oxford.

Your main tasks will be:

  • Adapting existing and developing improved experimental protocols for the high-throughput analysis of AMR in a CA-PA co-infection model
  • Determining the underlying mechanisms that alter stress tolerance in a CA-PA co-infection model;
  • Performing Adaptive Laboratory Evolution (ALE) and high-throughput proteomics experiments to monitor the emergence of tolerance and resistance in CA-PA communities;
  • Identifying synergistic mechanisms that enable co-infecting pathogens to establish persistent communities and lead to worse patient outcomes;
  • Promoting and fostering awareness about co-infections and their role in AMR emergence;
  • Lead and support the preparation of scientific reports and journal articles.

You will get access to:

  • State-of-the-art research equipment and highly international and collaborative environments both at the Charité - Universitätsmedizin Berlin and University of Oxford;
  • Extended stays at each academic institution;
  • Opportunity to work in close contact with other basic- and clinical-research groups at Charité in the heart of Germany's vibrant capital;
  • Opportunity to work in close contact with other research groups within the Department of Zoology at the University of Oxford, one of the world's leading research universities;

  • Potential to lead multiple projects and a high degree of academic freedom

Requirements:

Essential:
  • PhD/Doktorgrad or equivalent in natural sciences (Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields)
  • Experience of designing and running experiments with microbial cultures (bacteria and/or fungi) in the laboratory
  • Hands-on experience with key biochemical and molecular biological methods

Highly desirable:

  • Experience with systems biology projects, high-throughput methodologies
  • Experience with analytical and omics methods (LC-MS, NGS)
  • Basic ability to analyse data in R or Python
  • Good communication skills for collaborative work

Any of the following will be a plus:
  • Proficiency in data analysis using R
  • Interest in multispecies communities, host-pathogen interactions, or related topics

How to apply:

Working language is English. Applicants with multidisciplinary background or unusual career paths are also encouraged to apply.

Details of contact person:
Prof. Markus Ralser
Tel: +49 30 450 528141
E-Mail: markus.ralser@charite.de