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Char­ité

The Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin is a joint medi­cal faculty, which ser­ves both Freie Uni­ver­si­tät Ber­lin and Hum­boldt Uni­ver­si­tät zu Ber­lin. As one of the lar­gest uni­ver­sity hos­pi­tals in Europe with an important history, it plays a lea­ding role in rese­arch, tea­ching and cli­ni­cal care. The Cha­rité uni­ver­sity hos­pi­tal has also made a name for its­elf as a modern busi­ness with cer­ti­fi­ca­ti­ons in the medi­cal, cli­ni­cal and manage­ment fields.

Doc­to­ral Stu­dent (m/f)

CC06, Kli­nik für Radio­lo­gie | Cha­rité Cam­pus Mitte

Work­ing field:

Exper­i­mentelle Radi­olo­gie, Col­lab­or­at­ive Research Cen­ter (CRC) SFB 1340 "In vivo Visu­al­iz­a­tion of Extra­cel­lu­lar Mat­rix Patho­logy" (Mat­rix in Vis­ion), Pro­ject B03 "Tar­get­ing Extra­cel­lu­lar Mat­rix Changes Induced by an Altered Homeo­stasis of Phos­phate Meta­bol­ism". Within this pro­ject a doc­toral pos­i­tion is avail­able.

The sum­mar­ized hypo­thesis for this pro­ject is that uremic car­di­omy­opathy (UC) is accom­pan­ied by a patho­lo­gic increase of the glyc­osa­minoglycan (GAG) com­pon­ent of the myocar­dial extra­cel­lu­lar mat­rix (ECM) and that these changes can be detec­ted and char­ac­ter­ized by in vivo Mag­netic Res­on­ance Ima­ging (MRI) using appro­pri­ate cationic ima­ging probes as well as by elas­t­ography-based in vivo mag­netic res­on­ance ima­ging (MRI).

  • Exper­i­mental work with cell cul­tures (e.g. THP cells, fibro­cytes) under vary­ing phos­phate con­cen­tra­tions of the medium, ana­lysis of the pro­duced ECM-com­pon­ents, incub­a­tion with vari­ous cationic ima­ging probes and ana­lysis of the bind­ing of these probes to ECM com­pon­ents.
  • In vivo research using a model for UC (adenin fed small animal). par­ti­cip­a­tion in and sup­port of in vivo ima­ging using small animal MRI, pre­par­a­tion of the tis­sue samples (heart and other organs) for ex vivo MRI and 1H relax­o­met­rie, and for his­to­chemic and immun­o­his­to­chemic micro­scopy. Fur­theron pro­cessing of tis­sue samples for bio­chem­ical ana­lysis, espe­cially for char­ac­ter­iz­a­tion of ECM com­pon­ents.
  • Assist­ance in the invest­ig­a­tion of bind­ing of cationic iron oxide nan­o­particles and Gad­olinium com­pounds to GAGs using spec­tro­scopic and relax­o­met­ric meth­ods.
  • Assist­ance in the invest­ig­a­tion of the vis­coelastic prop­er­ties of tis­sues using multiscale elas­t­ography.
A spe­cial focus will be on on the elu­cid­a­tion of the struc­tures of GAGs and how these struc­tures cor­rel­ate with the bind­ing of ima­ging probes and the dis­ease pro­cess.

We offer col­lab­or­at­ive super­vi­sion from basic sci­ent­ists and clin­ical experts, embed­ded in one of the most dense and innov­at­ive aca­demic regions in Europe, includ­ing the top-rated teach­ing hos­pital Char­ité with Europe's largest radi­olo­gical depart­ment.

Require­ments:

We are loo­king for highly moti­va­ted, inqui­si­tive, enthu­si­astic, and result-dri­ven can­di­da­tes for the doc­to­ral posi­tion with an excel­lent aca­de­mic record and prior rese­arch expe­ri­ence. Can­di­da­tes should ide­ally hold Mas­ter’s degrees in Bio­logy, Medi­cine or rela­ted disci­pli­nes, which are rele­vant for suc­cess­ful rese­arch in the above men­tio­ned pro­ject.

If inte­rested, please send your app­li­ca­tion in Eng­lish as a sin­gle elec­tro­nic docu­ment (in PDF for­mat) to
matthias.taupitz@charite.de, cc to maria-katharina.kuhn@charite.de. Please include

  • a com­plete and up-to-date cur­ri­cu­lum vitae
  • names and con­tact details of at least 2 refe­ren­ces
  • Bache­lor’s and Mas­ter’s tran­scripts

How to ap­ply:

Con­tact for fur­ther inform­a­tions:

matthias.taupitz@charite.de
joerg.schnorr@charite.de
Tel.:030 450 627201